Richard Vallee
نویسنده
چکیده
Richard Vallee is at Columbia University, College of Physicians and Surgeons in New York City. He received his BA degree from Swarthmore College, where he first majored in chemistry and then biology. In his last semester he was introduced to the new field of cell biology and the then recently identified structures called microtubules. He did his PhD at Yale in protein biophysics, and then began work on microtubules and their associated proteins as a postdoc in the laboratory of Gary Borisy. Subsequently, his own lab was responsible for the discovery of the motor protein cytoplasmic dynein and the endocytic GTPase dynamin, each of which has proven to play a central role in substantial aspects of cell biology.
منابع مشابه
MAP 1C is a motor
MAP 1C is a motor hen the protein dynein was discovered to provide the flagellar bending force to axonemal microtubules (MTs) (Gibbons, 1963), “people had jumped to the reasonable hypothesis that dynein was perhaps also involved in other microtubule movements,” recalls Richard Vallee (Columbia University Medical Center, New York, NY). But by the 1980s, no such cytoplasmic motor proteins had bee...
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Spontaneous mutations in the human LIS 1 gene are responsible for Type I lissencephaly (" smooth brain ). The distribution of neurons within the cerebral cortex of lissencephalic children appears randomized, probably owing to a defect in neuronal migration during early development. LIS 1 has been implicated in the dynein pathway by genetic analyses in fungi. We previously reported that the vert...
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Three families of cytoskeletal motor protein – the myosins, kinesins and dyneins – have evolved to mediate transport of cells and of structures and materials within cells in eukaryotes. Whereas myosin uses actin polymers to carry out its tasks, kinesin and dynein are microtubule-associated motors. Dyneins use energy from ATP hydrolysis to power a wide variety of cellular functions. Although at ...
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Following receptor-mediated uptake into endocytic vesicles and escape from the endosome, adenovirus is transported by cytoplasmic dynein along microtubules to the perinuclear region of the cell. How motor proteins are recruited to viruses for their own use has begun to be investigated only recently. We review here the evidence for a role for dynein and other motor proteins in adenovirus infecti...
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ورودعنوان ژورنال:
- Current Biology
دوره 17 شماره
صفحات -
تاریخ انتشار 2007